|
KMID : 1134820180470030347
|
|
Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 3 p.347 ~ p.351
|
|
|
Oral Glucose and Maltose Tolerance Test and Inhibition Effect of α-Glucosidase of Ecklonia cava Extract (Seapolynol) and Dieckol
|
|
Jeon Hui-Jeon
Kim Sung-Ho
Lee Boo-Yong
|
|
|
Abstract
|
|
|
|
Ecklonia cava, a brown seaweed native to the seas of Korea and Japan, includes various polyphenolic compounds. Seapolynol and its major compound dieckol derived from Ecklonia cava have various biological activities; however, their effect as a hypoglycemic agent has not been sufficiently investigated. Therefore, we investigated the effects of seapolynol and dieckol on α-glucosidase inhibition, based on the oral glucose tolerance test (OGTT) and oral maltose tolerance test (OMTT) in in vivo. α-Glucosidase inhibition activities significantly increased in response to 100 μg/mL seapolynol and 50 and 100 μM doses of dieckol. In addition, OGTT and OMTT of seapolynol and dieckol treated C57BL/KsJ-db/db mice were conducted. Specifically, seapolynol and dieckol were administrated at low and high doses for 6 weeks, after which glucose and maltose (1 g/kg body weight) were administrated orally following 12 h of starvation. Blood glucose levels were measured 30, 60, 90, and 120 min after administration of glucose and maltose. Mice that received high doses of seapolynol and dieckol showed significant 40% and 35% reductions in the area under the curve of blood glucose level, respectively. Moreover, blood glucose level of seapolynol (24.9 mmol/L) and dieckol (22.3 mmol/L) high dose groups were reduced compared to control group (31.6 mmol/L) when maltose administrated after 30 min. These results indicate that seapolynol and dieckol have the potential for use as functional materials for the treatment of hyperglycemia.
|
|
|
KEYWORD
|
|
|
seapolynol, dieckol, α-glucosidase inhibition activity, OGTT, OMTT
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|